ultrastructural study, and morphological analysis and
biochemical methods with identification of endonucleosomal DNA cleavage
and characteristic laddering of DNA fragments. Furthermore, in the nervous
system, the timing with regard to disease onset, the tempo of apoptosis
during the disease course, and the potential restriction to one cell class in a
complex tissue with many cell classes further complicates the identification
and evaluation of apoptosis as a disease process in many illnesses.