Last few decades, various extraction techniques were used to extract pectin from different kind of plant materials. Among variouskinds of extraction techniques, the efficiency of microwave irradiation is significantly higher, when compared to the conventionalextraction methods. When microwave irradiation is used to extract the pectin, two principal mechanisms are simultaneously function-ing. One of these is a rapid increase in temperature, which reducesemulsion viscosity and breaks the outer film of sample, thusimprove the extraction yield. The other is molecular rotation, whichneutralizes the Zeta potential. This phenomenon rearrange theelectrical charges surrounding the molecules, resulting in enhancedmovement of ions which increase the efficiency of extraction pro-cess. However, best of our knowledge MAE is not employed forthe extraction of pectin from dragon fruit. Hence, the objectives ofthis study were to estimate the influence of various MAE extractionconditions on the yield of dragon fruit pectin. Moreover, Responsesurface methodology (RSM) coupled with Box–Behnken responsesurface design (BBD) was used to optimize and model the presentextraction process.