Abstract
Drugs derived from marine organisms are currently used to cure
infectious diseases. Marine invertebrates collected from the intertidal
regions of the Indian coast have shown promising biological activities. Sea
cucumbers are soft-bodied worm-like echinoderms which belong to the
class Holothuroidae. Anti inflammatory activity was detected using
Carrageenan induced rat paw edema method. The analgesic activity was
performed using tail immersion method. Antipyretic activity was analysed
using Brewer’s yeast induced hyperpyrexia method.CNS was determined
using Locomotor activity. Immunomodulatory activity was tested using
Carbon clearance test. Antioxidant activity was measured using DPPH
method. Pharmacological studies showed that the anti inflammatory
bustle of methanol extracts in Holothuria atra at the concentration of 100
and 200 mg/kg, p.o on rats showed significant decrease in the paw
thickness in a dose dependent manner when compared to that of the
control, at the 5th hour of administration. Similarly the highest inhibition
rate seen in H. atra extracts was 84% showed analgesic activity. Then
antipyretic, immunomodulatory and CNS depressant activities were found
to be moderate. The methanol extract of H.atra showed high antioxidant
activity with IC50 value of 300. Overall results provide information that sea
cucumber H. atra could be explored as a potential source of high-value
bioactive metabolites and could be used in the pharmaceutical industry.
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