Abstract: Clostridium difficile infection rates are Climbing in frequency and severity, and the
spectrum of susceptible patients is expanding beyond the traditional scope of hospitalized
patients receiving antibiotics. Fecal microbiota transplantation is becoming increasingly
accepted as an effective and safe intervention in patients with recurrent disease, likely due to
the restoration of a disrupted microbiome. Cure rates of > 90% are being consistently reported
from multiple centers. Transplantation can be provided through a variety of methodologies,
either to the lower proximal, lower distal, or upper gastrointestinal tract. This review
summarizes reported results, factors in donor selection, appropriate patient criteria, and
the various preparations an