The search of PubMed for human clinical trial studies
retrieved 233 articles. PsycINFO generated 251 articles.
Web of Science generated 287 articles.There were a total of
771 articles; of these, 161 were duplicates. The use of the
search term“Theobromine” generated many hits related to
the drug pentoxifylline. A number of articles were also
related to caffeine, and a few articles also used chocolate-
flavored foods or drinks as a vehicle for other drugs. In
total, 465 articles were clearly not relevant to the subject
area and were rejected on the basis of the title and abstract.
Of the remaining articles, 75 were related to eating behaviors,
49 were related to mechanisms of action, and 21 were
related to mood and cognitive function (4 of which were
included under both mood and cognition categories). Of