Glucose passes out of the cells and into the interstitial fluid, then into the bloodstream. Once individual glucose molecules move into your bloodstream, your blood glucose level rises rapidly. The high sugar content of the soda causes a spike in blood glucose, triggering a hyperglycemic condition. The pancreas detects an increase in glucose levels in the bloodstream. In response, the beta cells of the pancreatic islets produce and secrete the hormone insulin into the bloodstream