For a quick start to help clear spots, use daily for 5 days in a row. Apply onto clean skin at night. Lightly wipe the Proactiv+™ Mark Fading Pads across the face, neck or any area that needs to be treated - avoiding the eye area. Do not wash off. For best results use with your Proactiv+ 3 step system in the morning. May be used daily as needed. If bothersome dryness or peeling occurs, reduce application use. If going outside, use a sunscreen. Tip: For best results, use overnight. Apply after Skin Smoothing Exfoliator (Step One), leave on and continue with the Proactiv+ system.