3.2. NF-_B inhibitory activities and effects on LPS-induced
pro-inflammatory mediators PGE2, IL-6, IL-1ˇ and TNF-˛ release.
Gynura pseudochina var. hispida (MeOH) and Oroxylum indicum
(EtAc) showed the strongest NF-_B inhibitory effects and they also
inhibited the release of IL-1_ and PGE2 (Table 2). Interestingly,
Muehlenbeckia platyclada (EtAc and MeOH) showed the highest
level of inhibition on the release of several pro-inflammatory
cytokines such as IL-6, IL-1_ and TNF-_, but did not present
any inhibitory effects on the activation of NF-_B. In addition,
a number of extracts activated NF-_B or increased the synthesis of the pro-inflammatory mediators which will require further
investigation.
3.2. NF-_B inhibitory activities and effects on LPS-induced
pro-inflammatory mediators PGE2, IL-6, IL-1ˇ and TNF-˛ release.
Gynura pseudochina var. hispida (MeOH) and Oroxylum indicum
(EtAc) showed the strongest NF-_B inhibitory effects and they also
inhibited the release of IL-1_ and PGE2 (Table 2). Interestingly,
Muehlenbeckia platyclada (EtAc and MeOH) showed the highest
level of inhibition on the release of several pro-inflammatory
cytokines such as IL-6, IL-1_ and TNF-_, but did not present
any inhibitory effects on the activation of NF-_B. In addition,
a number of extracts activated NF-_B or increased the synthesis of the pro-inflammatory mediators which will require further
investigation.
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