Reduced or absent vital proteins lead to a lack of tensile strength within the skin and mucous membranes, resulting in blisters or skin stripping following minor friction and trauma. Severe EB leads to early development of recalcitrant wounds that are perpetuated by critical colonisation, presence of biofilms and infection. In line with current recommendation and to avoid further antibiotic resistance in children with EB, if local colonisation of wounds is observed the use of topical antimicrobial agents are advised. Antibiotic use should be reserved for severe systemic infections caused by Group A streptococcus.