The patient returned to Europe at 28 weeks of
gestation. Ultrasonographic examination that
was performed at 29 weeks of gestation showed
the first signs of fetal anomalies, and she was
referred to the Department of Perinatology. At
that time, she also noticed reduced fetal movements.
Ultrasonography that was performed at
32 weeks of gestation confirmed intrauterine
growth retardation (estimated third percentile
of fetal weight) with normal amniotic fluid, a
placenta measuring 3.5 cm in thickness (normal
size) with numerous calcifications, a head circumference
below the second percentile for gestation
(microcephaly), moderate ventriculomegaly,
and a transcerebellar diameter below the second
percentile. Brain structures were blurred, and
there were numerous calcifications in various
parts of the brain (Fig. 1A and 1B). There were
no other obvious fetal structural abnormalities.
Fetal, umbilical, and uterine blood flows were
normal on Doppler ultrasonography.
The patient returned to Europe at 28 weeks ofgestation. Ultrasonographic examination thatwas performed at 29 weeks of gestation showedthe first signs of fetal anomalies, and she wasreferred to the Department of Perinatology. Atthat time, she also noticed reduced fetal movements.Ultrasonography that was performed at32 weeks of gestation confirmed intrauterinegrowth retardation (estimated third percentileof fetal weight) with normal amniotic fluid, aplacenta measuring 3.5 cm in thickness (normalsize) with numerous calcifications, a head circumferencebelow the second percentile for gestation(microcephaly), moderate ventriculomegaly,and a transcerebellar diameter below the secondpercentile. Brain structures were blurred, andthere were numerous calcifications in variousparts of the brain (Fig. 1A and 1B). There wereno other obvious fetal structural abnormalities.Fetal, umbilical, and uterine blood flows werenormal on Doppler ultrasonography.
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