Abstract
Pumpkin seeds has long been used as a source of nutrition. Based on its content, it is possible that part of this plant used as
immunonutrient. The purpose of this research is to study the immunomodulatory activity of pumpkin seeds. It effects on the nonspecific
immune response was determined through carbon clearance test, organ indexes (liver, spleen and thymic gland) and mice
peritoneal exudate activity (PEA). The effects on specific immune response were determined through total antibody titre, delayed
type of hypersensitivity (DTH) reaction and number of lymphocytes. On non specific immune response test, pumpkin seed at a
low dose (PLD-3.8g/kg bw) and at a high dose (PHD-7.6g/kg bw) showed immunostimulanting effect with phagocytic index of
1.219 and 1.347, respectively. PHD increased PEA activity (p