We have concluded, along with many other authors, that there are no significant differences in efficacy between AAPs, with the exception of clozapine and ziprasidone.5,6,10 Clozapine demonstrated superior efficacy in treatment-resistant patients with EOS6,10 and probably would demonstrate such efficacy in the general EOS population if its use, due to hematological side effects, were not limited to refractory patients. The position of ziprasidone for treatment of EOS, on the other hand, has been weakened by negative results from a pediatric RCT,5 and according to the American Academy of Child and Adolescent Psychiatry, it should not be considered for EOS,2 even though its efficacy in adult schizophrenia is beyond doubt.