the results of skin irritation tests indicated that there were no irritation in
normal volunteers for cream base, cream containing aril oil and cream containing NLC
and cream containing aril oil-loaded NLC. The wrinkle reducing capacity test indicated
that the cream containing aril oil and cream containing aril oil-loaded NLC presented
significantly reducing of wrinkle. But, the cream containing aril oil-loaded NLC
exhibited significantly the capability to reduce skin wrinkle higher than cream containing
aril oil.