Diversefunctionsofthehomeodomaintra

DiversefunctionsofthehomeodomaintranscriptionfactorBARX1includeWnt-dependent,non-cell
autonomous specification ofthestomachepithelium,tracheo-bronchialseptation,andWnt-indepen-
dent expansionofthespleenprimordium.Tightspatio-temporalregulationof Barx1 levels inthe
mesentery andstomachmesenchymesuggestsadditionalroles.Todeterminethesefunctions,weforced
constitutiveBARX1expressioninthe Bapx1 expressiondomain,whichincludesthemesenteryand
intestinal mesenchyme,andalsoexamined Barx1
/
embryos infurtherdetail.Transgenicembryos
invariablyshowedintestinaltruncationandmalrotation,inpartreflecting abnormalleft-rightpattern-
ing. EctopicBARX1expressiondidnotaffectintestinalepithelium,butintestinalsmoothmuscle
developed withfeaturestypicalofthestomachwall.BARX1,whichisnormallyrestrictedtothe
developing stomach,drivesrobustsmoothmuscleexpansioninthisorganbypromotingproliferationof
myogenicprogenitorsattheexpenseofothersub-epithelialcells.Undifferentiatedembryonicstomach
and intestinalmesenchymeshowedmodestdifferencesinmRNAexpressionandBARX1wassufficient to
induce muchofthestomachprofile inintestinalcells.However,limitedbindingat cis-regulatorysites
implies thatBARX1mayactprincipallythroughothertranscriptionfactors.Genesexpressedectopically
in BARX1þ intestinal mesenchymeandreducedin Barx1
/
stomachmesenchymeinclude Isl1, Pitx1,
Six2 and Pitx2, transcriptionfactorsknowntocontrolleft-rightpatterningandinfluence smoothmuscle
development. ThesumofevidencesuggeststhatpotentBARX1functionsinintestinalrotationand
stomach myogenesisoccurthroughthissmallgroupofintermediarytranscriptionfactors.

ผลลัพธ์ (ไทย) 1:

ขึ้นอยู่ กับ DiversefunctionsofthehomeodomaintranscriptionfactorBARX1includeWnt ไม่ใช่เซลล์ข้อมูลจำเพาะเกี่ยวกับเขตปกครองตนเอง ofthestomachepithelium, andWnt, tracheo-bronchialseptation-indepen -เด็นท์ expansionofthespleenprimordium Barx1 Tightspatio temporalregulationof ระดับในการmesentery andstomachmesenchymesuggestsadditionalroles Todeterminethesefunctions, weforcedconstitutiveBARX1expressioninthe Bapx1 expressiondomain, whichincludesthemesenteryandลำไส้ mesenchyme, andalsoexamined Barx1 / infurtherdetail โคลน Transgenicembryosinvariablyshowedintestinaltruncationandmalrotation, inpartreflecting abnormalleft-rightpattern -ไอเอ็นจี EctopicBARX1expressiondidnotaffectintestinalepithelium, butintestinalsmoothmusclewithfeaturestypicalofthestomachwall พัฒนา BARX1, whichisnormallyrestrictedtotheพัฒนาท้อง drivesrobustsmoothmuscleexpansioninthisorganbypromotingproliferationofmyogenicprogenitorsattheexpenseofothersub-epithelialcells Undifferentiatedembryonicstomachและ intestinalmesenchymeshowedmodestdifferencesinmRNAexpressionandBARX1wassufficient การก่อให้เกิด muchofthestomachprofile inintestinalcells อย่างไรก็ตาม cis limitedbindingat-regulatorysitesหมายถึง thatBARX1mayactprincipallythroughothertranscriptionfactors.Genesexpressedectopicallyในลำไส้ mesenchymeandreducedin BARX1þ Barx1 / stomachmesenchymeinclude Isl1, Pitx1Six2 และ Pitx2, smoothmuscle transcriptionfactorsknowntocontrolleft-rightpatterningandinfluenceการพัฒนา ThesumofevidencesuggeststhatpotentBARX1functionsinintestinalrotationandmyogenesisoccurthroughthissmallgroupofintermediarytranscriptionfactors ท้อง

ผลลัพธ์ (ไทย) 2:

DiversefunctionsofthehomeodomaintranscriptionfactorBARX1includeWnt ขึ้นอยู่กับที่ไม่ใช่เซลล์
ofthestomachepithelium ข้อกำหนดอิสระ tracheo-bronchialseptation,
andWnt-อิสระบุ๋มexpansionofthespleenprimordium.Tightspatio-temporalregulationof ระดับ Barx1 inthe
น้ำเหลือง
Bapx1 expressiondomain, whichincludesthemesenteryand
mesenchyme ลำไส้ andalsoexamined Barx1? /? ตัวอ่อน infurtherdetail.Transgenicembryos
invariablyshowedintestinaltruncationandmalrotation, inpartreflecting abnormalleft-rightpattern-
ไอเอ็นจี EctopicBARX1expressiondidnotaffectintestinalepithelium, butintestinalsmoothmuscle
พัฒนา withfeaturestypicalofthestomachwall.BARX1, whichisnormallyrestrictedtothe
พัฒนา intestinalmesenchymeshowedmodestdifferencesinmRNAexpressionandBARX1wassufficient ที่จะทำให้เกิดการmuchofthestomachprofile inintestinalcells.However, limitedbindingat ถูกต้อง-regulatorysites หมายถึง thatBARX1mayactprincipallythroughothertranscriptionfactors.Genesexpressedectopically ในลำไส้ mesenchymeandreducedin BARX1þ Barx1? /? stomachmesenchymeinclude Isl1, Pitx1, Six2 และ Pitx2, transcriptionfactorsknowntocontrolleft-rightpatterningandinfluence smoothmuscle พัฒนา ThesumofevidencesuggeststhatpotentBARX1functionsinintestinalrotationand myogenesisoccurthroughthissmallgroupofintermediarytranscriptionfactors กระเพาะอาหาร