Peptic ulcer disease (PUD) is an illness that affects many people worldwide. Despite advances in the understanding of PUD, its aetiology has not been completely elucidated. factors that could increase the incidence of PUD in the global population include stress, high consumption of alcohol. smoking. Helicobacter pylori drugs (NSAIDs) and ingestion of non-steroidal anti-inflammatory [1]. The use of NSAIDs. low-dose aspirin or dual anti-platelet