where W1 represents the weight loss relative to the function-
alized MSNs, W2 is the weight loss of MSNs before
modification, and M is the molecular weight of relative grafted
material.
3.2. Enzyme-Induced Drug Release. The in vitro release
behaviors were investigated in PBS buffer at a pH of 7.4
(physiological environment) and 5.0 (lysosome environment).
Herein, the DLC and DLE values of DOX@MSN-
GFLGR7RGDS/α-CD nanoparticles were ∼4.3% and 35.7%,
respectively. The detailed drug-release profile of DOX@MSN-
GFLGR7RGDS/α-CD nanoparticles is shown in Figure 4. In