Description
Fibroblast growth factors (FGFs; see 131220) are a family of polypeptide growth factors involved in a variety of activities, including mitogenesis, angiogenesis, and wound healing. FGF receptors, such as FGFR3, contain an extracellular domain with either 2 or 3 immunoglobulin (Ig)-like domains, a transmembrane domain, and a cytoplasmic tyrosine kinase domain (summary by Keegan et al., 1991).