Currently there is little biogas utilization at US WWTPs. Most biogas is flared while some is used for onsite process heat and power production. Case studies of co-digestion of biosolids with organic wastes at field-scale show the use of co-digestion could overcome significant economic challenges including higher methane yield, more efficient digester volume utilization and reduced biosolids production. These findings could provide guidance in retrofitting existing facilities or in designing new biogas production and utilization systems. The RFS2 ruling increases market certainty, hence reduces risk. The evaluation of applications of co-digestion at WWTP scales ranging from 1 million gallons per day (MGD) to 375 MGD determined its potential feasibility for different types of digester operation, organic waste and loading rate as well as effectiveness of providing energy self-sufficiency at the WWTPs. This work could improve economics of anaerobic digestion at WWTPs, enabling viable and sustainable biogas industry and offsetting costs for wastewater management.