Encompassing C. albicans, the behavior was rather similar to the one detected in Gram-positive bacteria: the inhibitory effect increased slightly as the MW increased,
where 0.25% (w/v) of each COS was needed to attain the same inhibitory effect as that caused by 0.15% (w/v) of high MW chitosan. A similar tendency for C. albicans was also suggested elsewhere [24], where COS (ca. 1.4- 2.8 kDa) were reported to have no significant antimicrobial activity, whereas water-insoluble chitosans (ca. 400-
48 kDa) exhibited an inhibitory effect against C. albicans.