The findings of the present study are consistent with the growing body evidence indicating that in addition to the P53-dependent transcriptional program, its known influence on apoptosis and cell cycle arrest enhances the expression of key regulators of innate immunity pathways.P53 may extend its protective function by participating in antioxidant defense. Such activity should be at variance to the known prooxidant function of some stress-induced P53-responsive genes,which contribute to P53-induced cell death.All these findings suggest that the highly conserved nature of P53 among
eukaryotes may rely more on its role in host immunity rather than its functions as a tumor suppressor gene