Various therapeutically efficient traditional and natural agents are subjected to studies to identify their effects on drug-induced neurotoxicity causing behavioral and motor alterations. In our previous study, we reported the effectiveness of curcumin against CP-induced behavioral changes (Al Moundhri et al. 2013). Green tea extract (polyphenols) has been proved to exhibit an antidepressant activity against chemical-induced autistic animals (Banji et al. 2011) and also showed a neuroprotective effect in oxaliplatin-induced neuropathy (Lee et al. 2012). In a recent study, it was showed that aqueous extract of Orbignya phalerata improved locomotion and motor activity in mice (Silva et al. 2012). We will test the possible effects of several natural products on the motor and behavioral changes seen after acute CP administration, and investigate further the possible mechanisms of these motor and behavioral
changes in CP treated mice, including cognitive deficits.