Hair loss becomes one of individual big concerns about the
esthetic appearance, and the markets of cosmetics and pharmaceutics
for the hair re-growth and the protection of hair loss have
been markedly growing for a few decades. The causes of hair loss
are known to be depression, shame, isolation from the society,
stress caused by an increased social activity, air and water
pollutions, nutritional unbalance due to a bad dietary life, and etc.
[1]. That is, a mental state and a quality of life are closely related to
the hair loss. In addition, a genetic inheritance and an aging also
have a great effect on abnormal hair loss [2].
Many cytological, biochemical and molecular biological
researches have been done on hair loss and re-growth [3,4]. In
order to prevent an abnormal hair loss and promote a hair regrowth,
extensive studies have been tried on the developments of
pharmaceutics and their formulations [5]. Minoxidil was approved
by FDA as an over the counter drug and it is applied topically. The
mechanism of Minoxidil efficacy is believed to dilate blood vessels
surrounding hair bulbs and effectively deliver nutrients to them
[6]. 9 years later, finasteride was approved by FDA as an ethical the