Antianginal Drugs and Other Anti-ischaemic Drugs: Antianginal Drugs and Other Anti- ischaemic Drugs Department of Pharmacology NEIGRIHMS, Shillong
Learning Objectives!: Learning Objectives! Know the Basics of the Disease of Angina Pectoris Know the major classes of drugs used to treat angina and their clinically important mechanisms of action Know the basic Pharmacology of each class of antianginal drugs Know the major contraindications, toxicities, and drug interactions of each class of antianginal drugs Know the drugs of choice for treating different forms of angina Know which antianginal drug combinations
What is angina?: What is angina? Angina pectoris is a Syndrome characterized by sudden severe pressing substernal chest pain or heaviness radiating to the neck, jaw, back and arms. It is often associated with diaphoresis, tachypnea and nausea The primary cause of angina is an imbalance between myocardial oxygen demand and oxygen supplied by coronary vessels This imbalance may be due to: a decrease in myocardial oxygen delivery an increase in myocardial oxygen demand or both The discomfort abates when supply becomes adequate for demand. Typically angina lasts for seconds to minutes, up to 15 minutes Classically angina is not associated with ischemic cell death