Regarding the age of the patient (≤18 vs N18 years old) significant statistical difference for 4 markers evaluated was shown (Fig. 3). For TP (7.35 vs 7.05 g/dL, p: 0.002) and Palb (28.5 vs 21.9 mg/dL, p:5.33e−9) a significant positive correlation between marker concentration and age was found. On the contrary, for Ca (9.8 vs 10.01 mg/dL,p: 0.015) and P (3.3 vs 4.7 ng/mL, p: .3.14e−9) a negative correlation was found.