Dosage Adult: PO Parkinsonism Initial: 125 mg twice daily, increase at 3-4 day intervals if needed. Max: 8 g/day. When used w/ benserazide: Levodopa-naive patients: Initial: 50 mg 3-4 times/day (advanced stage: 100 mg 3 times/day), increase as directed, maintenance: 400-800 mg/day in divided doses; Patients previously on levodopa monotherapy: 10-15% of previous usual dose; Patients previously on other levodopa/dopa-decarboxylase combination therapy: Initial: 50 mg 3-4 times/day. When used w/ carbidopa: Levodopa-naive patients: Initial: 100 mg 3 times/day, increase as directed, maintenance: 0.75-2 g/day in divided doses; Patients previously on levodopa monotherapy: 20-25% of the dose previously taken 3 or 4 times daily; Patients previously on other levodopa/dopa-decarboxylase combination therapy: Initial dose should provide the same daily levodopa dose.
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