In summary, because of the great value of assessing human tumor suppressor gene expression in cancer prevention and therapy, this studywas done to provide uswith a good opportunity to analyze the relationship between human gene expression and sequence compositional features. Zhou et al. identified some similar significant correlations between tissues specific oncogenes and sequence compositional features in human tissues (Zhou et al., 2007). Our results are consistent with their observation and support the idea that some translational selections exist on synonymous codon usage pattern in genes involved in tumor progression. The understanding of different mechanisms involved in the regulation of tumor suppressor genes, in normal or tumor tissues, might lead to better images about cancer initiation and progression. It appears that these resultsmay provide some newpotential clues to understanding the translational selection on sequence features of human tumor suppressor genes. Besides, tissue-specificcodon usage also has implications for the optimal design of gene therapies targeted at specifictissues.