anti-proliferative
and molecular effects of herbs
(turmeric and Chinese
goldthread)
and their bioactives (curcumin and ar-turmerone, berberine and coptisine,
respectively)
were determined in isolation and in combination. Using CWR22Rv1 and HEK293
cells, cell proliferation (as assessed by the MTT assay) and NF-κB promoter activity (using a
luciferase reporter construct) were evaluated and synergy of action was assessed by the ChouTalalay
method utilizing
CompuSyn
®
software.