Although most persons can tolerate the amount of caffeine (250–350mg) in 3–4 8-oz cups of coffee each day, there is some evidence that caffeine consumption aggravates certain conditions, including the following: –Gastroesophageal reflux disease (GERD) –Peptic ulcer disease (PUD) –Migraines –Arrhythmias –Insomnia and other sleep disturbances