Our study presents many differences in the response of cell lines to the treatment. The viability of the cells treated with lycopene was time-dependent in MCF-7 and MDA-MB231 cells, an effect not observed in MDA-MB-235 cells. MCF-7 cells showed reduction of viability, more intensive after 96 h, reaching 25% without differences in the doses. After 48 h of exposure, the minimal inhibitory concentration was 2.5 μM, and the reduction reached 20% at the higher dose (10 μM). In parallel, a similar study showed that MCF7 cell line treated with lycopene did not present a dosedependent effect after 72 h of the treatment. This study also showed that despite its effect on MCF-7 viability, lycopene does not act on the MCF-10 cell line, reinforcing the importance of cell type in carotenoid action (31).