However, vaccinated groupers had a
significantly high RPS (nearly 98%) (Table 1). In the control group,
some of the groupers exhibited signs of streptococcosis infection,
which was confirmed by hematoxylin–eosin (HE) staining and 16S
rDNA sequence analysis. S. iniae could also be re-isolated from all
dead fish (Table 2). In contrast, no clinical signs of streptococcosis