Although there are no trials to test the effect of lowering tHcy on the incidence of dementia, a recent literature review showed that trials with high-risk subjects have shown positive re- sults of B-vitamin treatment in modifying the dementia dis- ease process [7]. The FACIT trial showed that folic acid supplementation could lower tHcy levels and delay age- related cognitive decline in people aged 50–70 years with high tHcy [9].