The present review is indicative of multiple useful
clinical effects of Centella asiatica especially in
the age-related cognitive decline. Further long-term
studies will help determine the exact mechanism
by which CA influences age-related changes in
mood and cognitive function. Also the purported
anxiolytic activity of CA is intriguing in view
of the proposed involvement of cholecystokinin
(CCK) in the pathophysiology of fear and anxiety.
However, the mechanism of action and possible
toxicity needs to be further investigated in a
large sample which may bring to the light, the
precise mechanisms for ameliorating many other
CNS related conditions like depression and sleep
disorders apart from anxiety. Moreover, more double
blind randomized clinical trials are needed for
investigating its sedative, analgesic, antidepressive,
antiviral and immunomodulatory effects that have
been demonstrated experimentally in animals.