แปลสัมมนาThe purpose of this study was to investigate anti-inflammatory activities of anthocyanin fractions (AF) from blackberries (BB), Korean raspberries (KR) and black raspberries (BR) and their major anthocyanins (cyanidin-3-glucoside [C3G] and cyanidin-3-rutinoside [C3R]) in inflamed intestinal epithelial Caco-2 cells. Nitrite scavenging activity of C3G was significantly higher than that of C3R and the AF measured by a chemical method. All the AF and individual anthocyanins significantly inhibit nitric oxide (NO) secretion, inducible NO synthase expression and nuclear factor-κB activation in the Caco-2 cells exposed to conditioned medium (CM) from lipopolysaccharide-stimulated RAW264.7 cells. In the CM-stimulated Caco-2 cells, C3G, BBAF and KRAF inhibited NO production significantly more than C3R and BRAF, and C3G and BBAF expressed nuclear factor E2-related factor 2 significantly more than the control. The individual anthocyanins also significantly downregulated intercellular adhesion molecule 1 in Caco-2 cell lines. The results suggest that anthocyanins in Rubus fruits, particularly C3G, may promote anti-inflammation in intestinal epithelial cells.