Summary
Hyperpigmentation disorders may occur when skin cells produce excessive amounts of
melanin. Additionally, abnormal skin surface cell turnover rates can cause skin to retain
excess melanin for prolonged time periods. Several substances have been discovered that
have the ability to restrict excess melanin production as well as accelerate cell turnover in
patients with pigmentation disorders.
When combined together, these agents can both interrupt melanogenesis at multiple
points in the biochemical pathway, as well as help mitigate the appearance of accumulated
melanin at the skin surface, leading to lighter and brighter skin.