of chitosan. After 30 days of immersion in the SBF, the formationof hydroxyapatite is confirmed by the appearance of two peaksof diffraction: at 25.9 (2◦) corresponding to the (0 0 2) apatitereflection and 31.8 (2◦) corresponding to the (2 1 1) apatite reflec-tion [33]. For all the scaffolds, the bioactivity is observed from15 days of immersion. Therefore, the content of 46S6 does nothave a significant effect on the bioactivity of scaffolds. Indeed,the hydroxyapatite appears for each scaffold. The bioactive glassreleases calcium, phosphorus and silicon ions in the SBF and allowsthe formation of hydroxyapatite. The ionic exchanges study wasperformed by using ICP-OES. However, a better crystallization ofhydroxyapatite is observed for 2CH-1BG. This phenomenon may berelated to the specific surface area of the samples. Having a largerspecific surface area and a larger pore volume, 2CH-1BG scaffoldspromotes the flow of the SBF through the material, favoring ionexchanges and forming a better crystallized hydroxyapatite.