ฉันรักแปลภาษาThe burden of malaria on the health and economics of the subtropical
countries is increasing due to the rapid spread of resistance
to the most of the classical drugs in use. It is estimated
that malaria affects the 500 million people across the world, causes
approximately 2.5 million deaths every year especially among the
children under the age of five years.1 Plasmodium falciparum is the
most virulent form of parasite among the four plasmodium species
infecting humans and is responsible for most of mortality.2 Currently
an effective therapeutic option for the treatment of resistant
malaria is combination therapy based on the natural endoperoxide
artemisinin and its semisynthetic derivatives.3 The combination
therapy is a viable option as the combination of drugs delays the
selection of resistance to the parasite but the cost of treatment is
much higher than monotherapy.4 So there is an urgent need for
new safer, more efficacious and affordable antimalarial agents as
the disease is prevalent mainly in the poor subtropical countries.