When a mosquito bites to cause infection through the skin into the bloodstream, the antigen binding to the FcγR of myeloid cell (monocytes/ macrophages/dendritic cell), Zika RNA replication, In order to increase the number in myeloid cell cause myeloid cell produced pro-inflammatory cytokines in blood or tissue inflammation than normal. The effect is caused shock syndrome (Circulatory disorders) and bleeding disorders. Therefore, pregnant women should take extra care. There is no vaccine to protect against Zika. The best way to avoid getting the virus is to avoid getting bit by mosquitoes.