Murphy is best known for composing the music for Guy Ritchie's Lock, Stock and Two Smoking Barrels, Michael Mann's Miami Vice, Matthew Vaughn's Kick-Ass, and the Danny Boyle films 28 Days Later, Millions, and Sunshine. His instrumental tracks "In the House – In a Heartbeat" and "Adagio in D Minor" have been featured in a variety of TV shows, commercials and film trailers.