Skin is frequently subjected to various injuries by physical and chemical means and is wounded, and initiated well-designed series of complicated events to reestablish its integrity and functions.
Particularly in many acute and chronic conditions such as partial, full or deep-thickness wound conditions, the naturally initiated sequence of event fails to regenerate the skin tissue and reestab- lish the functions [1,2]. Skin grafting remains as a conventional gold standard method to treat those of severe wound conditions. Extensive limitations accompanied by grafting include donor site shortage, scarring at donor site, pain and risk of infection make the grafting complicated. Therefore, tissue engineering is a promising approach that received greater attention to restore wounded skin tissue [3]. However, synthesizing a biomimetic three-dimensional (3D) scaffold is still a challenging task in tissue engineering since it necessitates biomaterials that promise biological and mechani- cal properties which facilitate successful restoration of skin and its functions. Until today, numerous natural and synthetic biomate- rials have been tested for the desired biological and mechanical