was able to demon strate for the first time in this disease, by means of indirect immunofluorescent techniques, the presence of circulating antibodies in the patient's serum that combine specifically with the fungus in the tissue.22 However, the fact that these antibodies were not demonstrated in the eosinophilic coat of the Splendore-Hoeppli phenomenon may suggest that the immunological reaction that takes place in entomophthoromycosis is different from that observed in other parasitic diseases (such as schistosomiasis) where antibodies to the parasite have been found in granular material of the Splen dore-Hoeppli reaction.We hope that the finding of these two new cases in a tropical country in Central America will stimulate the search for more cases of this peculiar mycosis, and that fur ther immunological studies will help in clarifying many of the special features that characterize this disease