Cryo-immunoEM of MIC2 localization during invasion of HFF cells. Left, a low magni®cation image depicts the anterior half of an invading parasite. Micronemes are stacked beneath the membrane along the lateral surface of the parasite (open arrow). The boxed region (lower left corner) representing the interface between the parasite and host cell surface is enlarged on the right. MIC2 is located at the moving junction region, which forms between the parasite surface membrane (open arrowheads) and the host plasma membrane (closed arrowheads). DG, dense granule; N, nucleus; PV, parasitophorous vacuole; HFF, human foreskin ®broblast; M, microneme.