Patterns of particular interest were the ASI subscales’ differential relationship with physiological hyperarousal for each of the sexes. In women, physical concerns predicted physiological hyperarousal, which is consistent with the multidimensional and hierarchical description of AS demonstrating the lower order factor’s ability to differentiate between symptoms of the anxiety disorders and depression. In men, however, physical concerns did not predict physiological hyperarousal, as it did in women and as it is described in the AS model; rather mental incapacitation was a significant predictor of physiological hyperarousal. Alternatively, physical concerns predicted social anxiety symptoms in men. These were the most substantive discrepancies observed between men and women in these relationships.