Authorities said that some 600 people are missing, an estimate based on the 125 homes that Thursday's landslide destroyed or damaged after heavy rains.
The landslide was triggered by heavy rain late Thursday in the town of Santa Catarina Pinula and small village of El Cambray II, 15 kilometers (9 miles) east of Guatemala City.
Thirty-four people were pulled out alive from the mud and rubble, while 25 others were injured, CONRAD officials said.
The impact of the heavy rain was exacerbated by a nearby river, officials said. Municipal authorities had recommended the community relocate last year.
Eight people had already died in previous weather-related events tied to Guatemala's rainy season, which lasts from May to November, according to government data.
Last year's rainy season was tied to 29 deaths and damage to more than 9,000 homes.