Ylang–Ylang oil is used in the food industry as a flavor ingredient. It is a complex chemical mixture in the form of an essential oil
extracted by water or water-and-steam distillation from the fresh flowers of Cananga odorata Hook. f. & Thomson. Ylang–Ylang oil has
been reported to cause dermal sensitization reactions in animals and humans, but it is unclear what constituent(s) within the essential oil
comprise the offending agent(s) and whether some Ylang–Ylang oils that have had certain constituent(s) removed are any less prone to
cause such allergic reactions. There is no indication in the literature that food exposure to Ylang–Ylang oil has caused allergic reactions.
One subchronic inhalation toxicity study, involving Ylang–Ylang oil as part of a larger fragrance raw materials mixture, gave no indication of causing adverse effects, but the relevance to risk assessment of oral food flavoring use exposures is likely minimal. No further
toxicity data for Ylang–Ylang oil have been reported. Notwithstanding the foregoing, Ylang–Ylang oil has a long history of fragrance
and food flavoring use, with no indication that its estimated consumption from food flavoring use (0.0001 mg/kg/day) has led to any
adverse human health effects. These data indicate that at the current level of intake as a food ingredient, Ylang–Ylang oil does not pose
a health risk to humans.
2007 Published by Elsevier Ltd