milkAbstractObjectives: To assess the effect of maternal breast milk supplementation on the developmentof exclusively breast-fed very low birth weight preterm infants at 12 months of corrected age.Methods: A randomized clinical trial with 53 infants followed-up after discharge from theneonatal unit until a corrected gestational age of 12 months. Newborns in the interventiongroup were breastfed exclusively with maternal milk and received 2 g of a multinutrient sup-plement (Pré-Nan®, Nestlé, Vevey, Switzerland) added to expressed breast milk twice a day untila corrected age of 4---6 months. The control group was exclusively breastfed without supplemen-tation. After monthly follow-up, developmental assessment was performed using the Bayley IIIScale.Results: There was no statistically significant difference on the Bayley III Scale between theintervention and control groups in any of the assessed domains: motor, cognitive, and commu-nication. However, scores in the three domains were always higher in the group that receivedthe supplement. There were a similar number of cases of developmental delay in both groups:seven (28%) in the group that received the supplement and nine (33.3%) in the group that wasexclusively breastfed.