Citrus extracts,particularlybergamotessentialoil(BEO)anditsfractions,havebeenfoundtoexhibit anticancer efficacy.However,thepoorwatersolubility,lowstabilityandlimitedbioavailabilityhave prevented theuseofBEOincancertherapy.Toovercomesuchdrawbacks,weformulatedBEOliposomes that improvedthewatersolubilityofthephytocomponentsandincreasedtheiranticanceractivity in vitro against humanSH-SY5Yneuroblastomacells.TheresultswarrantfurtherinvestigationofBEOliposomes for in vivo applications.