In the Philippines, despite of the extensive campaign of the government against dengue, there are evidences of increasing rates of dengue morbidity in the recent year [6]. Moreover, as to authors’ knowledge, no empirical data investigating knowledge and practices on dengue prevention within the Province of Samar, Philippines exists. Further, recent outbreaks of dengue in the province necessitated development of this study. The knowledge that could be gained in this investigation would guide public administrators to plan, design and initiate initiatives, programs, and policies relative to dengue prevention which could be used to address the ever growing problems on dengue fever infections.