Results highlight that for the medium temperature (MT) system [_5; 10] _C the R407f and R410a fluids allow to obtain higher COP and cooling capacity than R404a. Among them, R407f has higher cooling capacity but presents a lower COP respect to R410a. The average performances among the investigated scenarios are (1.47; 1297 W), (1.51; 1417 W), (1.75; 1324 W) for R404a, R407f, R410a, respectively. Such results indicate the R410a is a potential alternative for the MT system even if R407f also represents a suitable solution. Concerning the low temperature (LT) system [_25; _15] _C, R410a is not usable because of the compressor overheating. On the contrary, R407f presents comparable COP values respect to R404a, while it increases of about 10% the cooling capacity.