As previously discussed, a weight loss of 5 to 10 percent can significantly reduce the risk factors for diabetes (Knowler et al 2002) and cardiovascular disease in high risk patients (Douketis et al 2005). Orlistat has been shown to be safe and more effective than diet alone in modifying some of the risk of coronary artery disease (Lindgarde 2000). Independent of weight loss, it is important to look at the effect of Orlistat on obesity-related co morbidities.