Figure 1. Neural systems of relevance to major depressive disorder Key neural regions implicated in emotion and reward processing, and voluntary and automatic regulation of emotion are shown superimposed on a greyscale depiction of the human brain. DLPFC=dorsolateral prefrontal cortex. mPFC=medial prefrontal cortex. ACC=anterior cingulate cortex. OFC=orbitofrontal cortex. VLPFC=ventrolateral prefrontal cortex. Adapted with permission from reference 56